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Daily administration of two or more synaptogenic compounds simultaneously might overwhelm cellular synthetic capacity or trigger compensatory downregulation faster than either compound would alone, potentially favoring alternating administration schedules where different compounds are used on different days

The following antibodies were used for ChIP assay: anti-ACTL6A (Abcam, ab3882), anti-NRF2 (Cell Signaling Technology, 12721 s), and Rabbit IgG (ab37415) (Abcam, Cambridge, MA)

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(10) As for immune function, astaxanthin has been suggested to have two roles: (11) Modulating immune responses Regulating bacterial load and gastric inflammation Studies show that astaxanthin may be a powerful compound for regulating immune responses, oxidative damage, and inflammation in humans